Congenital hearing loss
AMH Korver, RJH Smith, G Van Camp… - Nature reviews Disease …, 2017 - nature.com
Congenital hearing loss (hearing loss that is present at birth) is one of the most prevalent
chronic conditions in children. In the majority of developed countries, neonatal hearing …
chronic conditions in children. In the majority of developed countries, neonatal hearing …
[HTML][HTML] Advances in gene therapy hold promise for treating hereditary hearing loss
L Jiang, D Wang, Y He, Y Shu - Molecular Therapy, 2023 - cell.com
Gene therapy focuses on genetic modification to produce therapeutic effects or treat
diseases by repairing or reconstructing genetic material, thus being expected to be the most …
diseases by repairing or reconstructing genetic material, thus being expected to be the most …
Role of connexin 43 in different forms of intercellular communication–gap junctions, extracellular vesicles and tunnelling nanotubes
TM Ribeiro-Rodrigues… - Journal of cell …, 2017 - journals.biologists.com
Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …
required to sustain active social networks. A fine-tuned communication between cells is vital …
Toward cochlear therapies
J Wang, JL Puel - Physiological reviews, 2018 - journals.physiology.org
Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …
[HTML][HTML] Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress
W Liu, Y Cui, J Wei, J Sun, L Zheng, J Xie - International journal of oral …, 2020 - nature.com
Homoeostasis depends on the close connection and intimate molecular exchange between
extracellular, intracellular and intercellular networks. Intercellular communication is largely …
extracellular, intracellular and intercellular networks. Intercellular communication is largely …
[HTML][HTML] Research progress in delineating the pathological mechanisms of GJB2-related hearing loss
Y Wang, Y Jin, Q Zhang, Y Xiong, X Gu… - Frontiers in Cellular …, 2023 - frontiersin.org
Hearing loss is the most common congenital sensory impairment. Mutations or deficiencies
of the GJB2 gene are the most common genetic cause of congenital non-syndromic …
of the GJB2 gene are the most common genetic cause of congenital non-syndromic …
Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea
SL Johnson, F Ceriani, O Houston… - Journal of …, 2017 - Soc Neuroscience
Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …
[HTML][HTML] Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space
Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity
that are critical for survival, maturation and circuit refinement. In the auditory system …
that are critical for survival, maturation and circuit refinement. In the auditory system …
[HTML][HTML] Supporting cells and their potential roles in cisplatin-induced ototoxicity
S Waissbluth, JC Maass, HA Sanchez… - Frontiers in …, 2022 - frontiersin.org
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss.
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …
[HTML][HTML] GJB2 gene therapy and conditional deletion reveal developmental stage-dependent effects on inner ear structure and function
J Guo, X Ma, JM Skidmore, J Cimerman… - … Therapy-Methods & …, 2021 - cell.com
Pathogenic variants in GJB2, the gene encoding connexin 26, are the most common cause
of autosomal-recessive hereditary deafness. Despite this high prevalence, pathogenic …
of autosomal-recessive hereditary deafness. Despite this high prevalence, pathogenic …