Targeting DNA methylation in diabetic kidney disease: A new perspective
Diabetic kidney disease (DKD) is a leading diabetic complication causing significant
mortality among people around the globe. People with poor glycemic control accompanied …
mortality among people around the globe. People with poor glycemic control accompanied …
Epigenomic and other evidence for cannabis-induced aging contextualized in a synthetic epidemiologic overview of cannabinoid-related teratogenesis and …
AS Reece, GK Hulse - … Journal of Environmental Research and Public …, 2022 - mdpi.com
Background: Twelve separate streams of empirical data make a strong case for cannabis-
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …
DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
The Rotterdam Study. Design update and major findings between 2020 and 2024
MA Ikram, BCT Kieboom, WP Brouwer… - European Journal of …, 2024 - Springer
Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes
I Khurana, H Kaipananickal, S Maxwell… - The Journal of …, 2023 - Am Soc Clin Investig
Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust
replication in large-scale genome-wide association studies. To understand the role of DNA …
replication in large-scale genome-wide association studies. To understand the role of DNA …
Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development
Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …
development, as they not only reflect metabolic changes but are also preserved and …
A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
Identifying genomic regions pertinent to complex traits is a common goal of genome-wide
and epigenome-wide association studies (GWAS and EWAS). GWAS identify causal genetic …
and epigenome-wide association studies (GWAS and EWAS). GWAS identify causal genetic …
DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation
Recent epigenome-wide studies suggest an association between blood DNA methylation
and kidney function. However, the pathological importance remains unclear. Here, we show …
and kidney function. However, the pathological importance remains unclear. Here, we show …
Genetic and epigenetic background of diabetic kidney disease
N Sandholm, EH Dahlström, PH Groop - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …