Riding the tiger–physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

MD Brand - Critical Reviews in Biochemistry and Molecular Biology, 2020 - Taylor & Francis
Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Manganese superoxide dismutase dysfunction and the pathogenesis of kidney disease

M Kitada, J Xu, Y Ogura, I Monno, D Koya - Frontiers in physiology, 2020 - frontiersin.org
The mitochondria are a major source of reactive oxygen species (ROS). Superoxide anion
(O2•–) is produced by the process of oxidative phosphorylation associated with glucose …

Novel insights into redox system and the mechanism of redox regulation

X Wang, C Hai - Molecular Biology Reports, 2016 - Springer
In view of the critical role of redox system in numerous physiological and pathophysiological
processes, it is important to clearly understand the family members and regulatory …

[HTML][HTML] Role of superoxide dismutase 2 gene Ala16Val polymorphism and total antioxidant capacity in diabetes and its complications

K Pourvali, M Abbasi, A Mottaghi - Avicenna journal of medical …, 2016 - ncbi.nlm.nih.gov
Diabetes Mellitus (DM) is a chronic heterogeneous disorder and oxidative stress is a key
participant in the development and progression of it and its complications. Anti-oxidant …

Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC‐1α Signaling in db/db Mice

S Hou, T Zhang, Y Li, F Guo… - Journal of diabetes …, 2017 - Wiley Online Library
Diabetic nephropathy (DN) is a major cause of end‐stage renal disease (ESRD).
Glycyrrhizic acid (GA) is an effective inhibitor of reactive oxygen species (ROS) production …

[HTML][HTML] Concentration/activity of superoxide dismutase isozymes and the pro-/antioxidative status, in context of type 2 diabetes and selected single nucleotide …

Ł Lewandowski, I Urbanowicz, M Kepinska… - Biomedicine & …, 2021 - Elsevier
The alterations in concentration/activity of superoxide dismutase isozymes in the context of
type 2 diabetes or obesity are well-described. Moreover, many hereditary factors, including …

Pro198Leu polymorphism in the glutathione peroxidase 1 gene contributes to diabetic peripheral neuropathy in type 2 diabetes patients

M Buraczynska, K Buraczynska, M Dragan… - Neuromolecular …, 2017 - Springer
Abstract Glutathione peroxidase 1 (Gpx1) is an endogenous antioxidant enzyme. The T
allele of the Pro198Leu polymorphism in the Gpx1 (rs1050450, 198C> T) gene is associated …

[HTML][HTML] Role of long non-coding RNA (LncRNA) LINC-PINT downregulation in cardiomyopathy and retinopathy progression among patients with type 2 diabetes

T Zha, F Su, X Liu, C Yang, L Liu - Medical science monitor …, 2019 - ncbi.nlm.nih.gov
Role of Long Non-Coding RNA (LncRNA) LINC-PINT Downregulation in Cardiomyopathy and
Retinopathy Progression Among Patients with Type 2 Diabetes - PMC Back to Top Skip to main …

Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

V Kidir, E Uz, A Yigit, A Altuntas, B Yigit, S Inal, E Uz… - Renal …, 2016 - Taylor & Francis
Introduction The aim of this study was to evaluate the potential association of single gene
polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 …

Therapeutic implications of superoxide dismutase and its importance in kinase drug discovery

N Kaur, AK Sharma, A Shakeel… - Current Topics in …, 2017 - ingentaconnect.com
In recent years, several scientific investigations have reported the therapeutic implications of
superoxide dismutase (SOD) against oxidative stress and-induced pathology in clinical and …