Recent developments on the crosstalk between STAT3 and inflammation in heart function and disease
The transcription factor STAT3 has a protective function in the heart. Until recently, the role of
STAT3 in hypertension-induced cardiac hypertrophy was unsettled. Earlier studies revealed …
STAT3 in hypertension-induced cardiac hypertrophy was unsettled. Earlier studies revealed …
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
F Boehi, P Manetsch, MO Hottiger - Cell discovery, 2021 - nature.com
Signaling cascades provide integrative and interactive frameworks that allow the cell to
respond to signals from its environment and/or from within the cell itself. The dynamic …
respond to signals from its environment and/or from within the cell itself. The dynamic …
SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function
The clinical application of doxorubicin (Dox) in cancer therapy is limited by its serious
cardiotoxicity. Our previous studies and others have recognized that mitochondrial …
cardiotoxicity. Our previous studies and others have recognized that mitochondrial …
CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3
X Han, H Shi, Y Sun, C Shang, T Luan, D Wang… - Cell death & …, 2019 - nature.com
Myeloid-derived suppressor cells (MDSCs) comprise a critical component of the tumor
environment and CXCR2 reportedly plays a key role in the pathophysiology of various …
environment and CXCR2 reportedly plays a key role in the pathophysiology of various …
[HTML][HTML] The poly (ADP-ribosyl) ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy
The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the
pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by …
pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by …
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3
Sorting nexins (SNXs), the retromer-associated cargo binding proteins, have emerged as
critical regulators of the trafficking of proteins involved in the pathogenesis of diverse …
critical regulators of the trafficking of proteins involved in the pathogenesis of diverse …
Histone demethylase JMJD3 mediated doxorubicin-induced cardiomyopathy by suppressing SESN2 expression
Jumonji domain-containing 3 (JMJD3) protein, a histone demethylase protein, specifically
catalyzes the demethylation of H3K27 (H3K27me3) and regulates gene expression …
catalyzes the demethylation of H3K27 (H3K27me3) and regulates gene expression …
The role of PARP1 in monocyte and macrophage commitment and specification: future perspectives and limitations for the treatment of monocyte and macrophage …
M Sobczak, M Zyma, A Robaszkiewicz - Cells, 2020 - mdpi.com
Modulation of PARP1 expression, changes in its enzymatic activity, post-translational
modifications, and inflammasome-dependent cleavage play an important role in the …
modifications, and inflammasome-dependent cleavage play an important role in the …
Induced mitochondrial alteration and DNA damage via IFNGR-JAK2-STAT1-PARP1 pathway facilitates viral hepatitis associated hepatocellular carcinoma …
YG Cherng, YC Chu, VK Yadav, TY Huang, MS Hsieh… - Cancers, 2021 - mdpi.com
Simple Summary Hepatitis virus is a major risk factor for liver cancer. We analyzed possible
synergism between momelotinib and sorafenib in hepatitis virus-associated liver cancer …
synergism between momelotinib and sorafenib in hepatitis virus-associated liver cancer …
Respiratory Virus-Induced PARP1 Alters DC Metabolism and Antiviral Immunity Inducing Pulmonary Immunopathology
Previous studies from our laboratory and others have established the dendritic cell (DC) as a
key target of RSV that drives infection-induced pathology. Analysis of RSV-induced …
key target of RSV that drives infection-induced pathology. Analysis of RSV-induced …