Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with
multiple and outstanding cell biological functions. The history of their structural analysis …

Dengue is the most prevalent arboviral disease in humans and a major public health
problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially …

The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Abstract Background Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias)
from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release …

Sialic acids are terminal acidic monosaccharides, which influence the chemical and
biological features of glycoconjugates. Their removal catalyzed by a sialidase modulates …

Sialylated N-glycans play essential roles in the immune system, pathogen recognition and
cancer. This review approaches the sialylation of N-glycans from three perspectives. The …

The liver has recently been identified as a major organ for destruction of desialylated
platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are …

When refrigerated platelets are rewarmed, they secrete active sialidases, including the
lysosomal sialidase Neu1, and express surface Neu3 that remove sialic acid from platelet …