A new method is presented for synthesizing arbutin glycosides using α-glucosidase (AglA)
from Thermoplasma acidophilum and its glycosynthase mutant. An α-glycosynthase was …

This book provides an actual overview of the structure, function, and application of
carbohydrate-modifying biocatalysts. Carbohydrates have been disregarded for a long time …

Carbohydrates play an important part in a vast array of biological processes and therefore
glycomimetics are currently becoming a powerful class of novel therapeutics. 1 Amongst …

The presence of multiple functional groups and stereocentres in carbohydrates and
glycoconjugates make them challenging targets for synthesis. Although progress in …

Nucleophile mutants of retaining β-glycosidase can act as glycosynthases to efficiently
catalyze the synthesis of oligosaccharides. Previous studies proved that rice BGlu1 mutants …

Saturation transfer difference NMR spectroscopy is used to study non-covalent interactions
between four different glycostructure transforming enzymes and selected substrates and …

An interesting approach for the chemo-enzymatic synthesis of carbohydrates is the use of
glycosynthases, a class of mutant glycosidases derived from β-glycoside hydrolases …

D-Galactose in its furanose form is undoubtedly an enigma in glycosciences that has
triggered numerous chemical, physical and biological studies over the last thirty years. This …

The use of biocatalysts from yeast strains in organic synthesis is well established and covers
a broad range of reaction classes. A particularly interesting reaction class is the regio-and …

Glycosynthases are mutant glycosidases, which in the presence of activated glycosides and
suitable reaction conditions, synthesize oligosaccharides without hydrolysing them. This …