The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment
IMCM Rietjens, A Michael, HM Bolt, B Siméon… - Archives of …, 2022 - Springer
The “totality” of the human exposure is conceived to encompass life-associated endogenous
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety
CJ Borgert, C Fuentes, LD Burgoon - Archives of Toxicology, 2021 - Springer
Regulatory toxicology seeks to ensure that exposures to chemicals encountered in the
environment, in the workplace, or in products pose no significant hazards and produce no …
environment, in the workplace, or in products pose no significant hazards and produce no …
A review of stable isotope labeling and mass spectrometry methods to distinguish exogenous from endogenous DNA adducts and improve dose–response …
Cancer remains the second most frequent cause of death in human populations worldwide,
which has been reflected in the emphasis placed on management of risk from environmental …
which has been reflected in the emphasis placed on management of risk from environmental …
Changes in the physicochemical composition of Auricularia auricula during growth stages and control of endogenous formaldehyde
X Wang, Y Ren, Y Wang, H Li, J Huang, Z Wang… - Journal of Food …, 2022 - Elsevier
To maintain quality and reduce endogenous formaldehyde content in the edible fungus,
Auricularia auricula, the critical period of formaldehyde generation was identified and …
Auricularia auricula, the critical period of formaldehyde generation was identified and …
An updated mode of action and human relevance framework evaluation for formaldehyde-related nasal tumors
CM Thompson, R Gentry, S Fitch, K Lu… - Critical Reviews in …, 2020 - Taylor & Francis
Formaldehyde is a reactive aldehyde naturally present in all plant and animal tissues and a
critical component of the one-carbon metabolism pathway. It is also a high production …
critical component of the one-carbon metabolism pathway. It is also a high production …
Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat
RB Conolly, J Schroeter, JS Kimbell… - Toxicological …, 2023 - academic.oup.com
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma
(SCC). This outcome is well-characterized: including dose-response and time course data …
(SCC). This outcome is well-characterized: including dose-response and time course data …
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat …
RB Conolly, JL Campbell, HJ Clewell… - Toxicological …, 2023 - academic.oup.com
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is
complicated by (1) the uneven distribution of inhaled formaldehyde across the interior …
complicated by (1) the uneven distribution of inhaled formaldehyde across the interior …