[HTML][HTML] Potential role of bromelain in clinical and therapeutic applications

V Rathnavelu, NB Alitheen, S Sohila… - Biomedical …, 2016 - spandidos-publications.com
Pineapple has been used as part of traditional folk medicine since ancient times and it
continues to be present in various herbal preparations. Bromelain is a complex mixture of …

Bromelain: biochemistry, pharmacology and medical use

HR Maurer - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Bromelain is a crude extract from the pineapple that contains, among other components,
various closely related proteinases, demonstrating, in vitro and in vivo, antiedematous …

Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models

S Bayat, N Amiri, E Pishavar, F Kalalinia, J Movaffagh… - Life sciences, 2019 - Elsevier
Bromelain is a mixture of proteolytic enzymes present in all tissues of pineapple (Ananas
comosus). It is known as an efficient debriding agent in burn treatment. In this study, the …

Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis

K Bhui, S Tyagi, AK Srivastava, M Singh… - Molecular …, 2012 - Wiley Online Library
Bromelain, obtained from pineapple, is already in use clinically as adjunct in chemotherapy.
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …

[PDF][PDF] Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo

C Metzig, E Grabowska, K Eckert, K Rehse, HR Maurer - in vivo, 1999 - academia.edu
The thiol protease, bromelain, an extract from pine apple stern, was suggested to have
antuhrombotic and anticoagulant activities in vivo. We studied the effects of bromelain on …

Isolation and characterization of two forms of an acidic bromelain stem proteinase

T Harrach, K Eckert, HR Maurer, I Machleidt… - Journal of Protein …, 1998 - Springer
Two forms of an acidic bromelain proteinase isolated from crude bromelain, an extract from
pineapple stem, were found by a two-step FPLC purification procedure. The basic main …

Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.

K Eckert, E Grabowska, R Stange… - Oncology …, 1999 - spandidos-publications.com
The protease bromelain from pineapple was suggested for adjuvant therapy of malignant
diseases. We studied immunological effects of an orally applied bromelain drug on 16 …

Isolation and partial characterization of basic proteinases from stem bromelain

T Harrach, K Eckert, K Schulze-Forster, R Nuck… - Journal of protein …, 1995 - Springer
Crude bromelain extracts from pineapple stems (Ananas comosus) were fractionated by two-
step FPLC-cation-exchange chromatography. At least eight basic proteolytically active …

Bromelain reversibly inhibits invasive properties of glioma cells

BB Tysnes, HR Maurert, T Porwol, B Probst, R Bjerkvig… - Neoplasia, 2001 - Elsevier
Bromelain is an aqueous extract from pineapple stem that contains proteinases and exhibits
pleiotropic therapeutic effects, ie, antiedematous, antiinflammatory, antimetastatic …

Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma

K Pillai, J Akhter, TC Chua, DL Morris - Cancer investigation, 2013 - Taylor & Francis
Bromelain is a mixture of proteolytic enzymes that is capable of hydrolyzing glycosidic
linkages in glycoprotein. Glycoprotein's are ubiquitously distributed throughout the body and …