Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …
Migraine and the trigeminovascular system—40 years and counting
The underlying causes of migraine headache remained enigmatic for most of the 20th
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …
Post-traumatic headache: epidemiology and pathophysiological insights
Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one
of the most common sequelae of mild traumatic brain injury, also known as concussion …
of the most common sequelae of mild traumatic brain injury, also known as concussion …
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Pathophysiological mechanisms in migraine and the identification of new therapeutic targets
KA Haanes, L Edvinsson - CNS drugs, 2019 - Springer
Migraine is a strongly disabling disease characterized by a unilateral throbbing headache
lasting for up to 72 h for each individual attack. There have been many theories on the …
lasting for up to 72 h for each individual attack. There have been many theories on the …
Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine
MAM Al-Karagholi, H Ghanizada, CAW Nielsen… - Pain, 2021 - journals.lww.com
2. Materials and methods Fifty-four participants diagnosed with migraine without aura (MO)
according to the International Classification of Headache Disorders-3 36 were recruited …
according to the International Classification of Headache Disorders-3 36 were recruited …
Hypersensitivity to calcitonin gene–related peptide in Post‐traumatic headache
Objective To demonstrate that calcitonin gene–related peptide (CGRP) induces headache
exacerbation with migraine‐like features in patients with persistent post‐traumatic headache …
exacerbation with migraine‐like features in patients with persistent post‐traumatic headache …
Progress in traditional Chinese medicine for the treatment of migraine
Y Huang, N Ni, Y Hong, X Lin, Y Feng… - The American Journal of …, 2020 - World Scientific
Migraine is a recurrent disease with complex pathogenesis and is difficult to cure. At present,
commercially available western migraine drugs are prone to generate side effects while …
commercially available western migraine drugs are prone to generate side effects while …
PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP
A Kuburas, BN Mason, B Hing, AS Wattiez… - Journal of …, 2021 - Soc Neuroscience
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
The anti-CGRP antibody fremanezumab lowers CGRP release from rat dura mater and meningeal blood flow
M Dux, B Vogler, A Kuhn, KD Mackenzie, J Stratton… - Cells, 2022 - mdpi.com
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide
(CGRP) belong to a new generation of therapeutics that are effective in the prevention of …
(CGRP) belong to a new generation of therapeutics that are effective in the prevention of …