Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing
pain threshold. We now show that the B2 kinin receptor is expressed in rat dorsal horn …

Experiments were designed to investigate the role of kinin B1 and B2 receptors in Freund's
adjuvant (CFA)-induced inflammation and nociception responses by the use of B1 and B2 …

Essential hypertension is an insulin resistant state. Early insulin signaling steps are impaired
in essential hypertension and a large body of data suggests that there is a crosstalk at …

The mechanisms by which kinins induce hyperalgesia in the spinal cord were investigated
by using B1 or B2 knockout mice in conjunction with kinin selective agonists and …

Background Recent evidence suggests that the inducible kinin B 1 receptor (B 1 R)
contributes to pathogenic neuroinflammation induced by amyloid-beta (Aβ) peptide. The …

The paratrigeminal nucleus, which receives sensory input from trigeminal, glossopharyngeal
and vagus nerves, has efferent projections to bulbar, pontine and possibly to thalamic …

Injury to peripheral nerves often results in a persistent neuropathic pain condition that is
characterized by spontaneous pain, allodynia, and hyperalgesia. Nerve injury is …