Spinal dura mater: biophysical characteristics relevant to medical device development

SJ Nagel, CG Reddy, LA Frizon… - Journal of medical …, 2018 - Taylor & Francis
Understanding the relevant biophysical properties of the spinal dura mater is essential to the
design of medical devices that will directly interact with this membrane or influence the …

Intrathecal therapeutics: device design, access methods, and complication mitigation

SJ Nagel, CG Reddy, LA Frizon, MT Holland… - … : Technology at the …, 2018 - Elsevier
Introduction The intrathecal space remains underutilized for diagnostic testing, invasive
monitoring or as a pipeline for the delivery of neurological therapeutic agents and devices …

Kinematic analysis of the gait of adult sheep during treadmill locomotion: parameter values, allowable total error, and potential for use in evaluating spinal cord injury

S Safayi, ND Jeffery, SK Shivapour… - Journal of the …, 2015 - Elsevier
We are developing a novel intradural spinal cord (SC) stimulator designed to improve the
treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of …

Intradural spinal cord stimulation: performance modeling of a new modality

DJ Anderson, DR Kipke, SJ Nagel… - Frontiers in …, 2019 - frontiersin.org
Introduction: Intradural spinal cord stimulation (SCS) may offer significant therapeutic
benefits for those with intractable axial and extremity pain, visceral pain, spasticity …

Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device

KN Gibson-Corley, O Flouty, H Oya… - BioMed research …, 2014 - Wiley Online Library
Spinal cord stimulation has been utilized for decades in the treatment of numerous
conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer …

Revisiting intradural spinal cord stimulation: an introduction to a novel intradural spinal cord stimulation device

BD Dalm, SV Viljoen, NS Dahdaleh… - Innovative …, 2014 - degruyter.com
Background: Spinal cord stimulation has been in use for decades and is growing as a
therapeutic treatment option. A significant problem arising from the epidural location of the …

Contemporary approaches to preventing and treating infections of novel intrathecal neurostimulation devices

SJ Nagel, L Frizon, T Maiti, AG Machado, GT Gillies… - World neurosurgery, 2019 - Elsevier
Introduction Contemporary approaches to surgical site infections have evolved significantly
over the last several decades in response to the economic pressures of soaring health care …

Biomechanical performance of an ovine model of intradural spinal cord stimulation

S Safayi, ND Jeffery, DC Fredericks… - Journal of medical …, 2014 - Taylor & Francis
The authors are developing a novel type of spinal cord stimulator, designed to be placed
directly on the pial surface of the spinal cord, for more selective activation of target tissues …

Durotomy surrogate and seals for intradural spinal cord stimulators: apparatus and review of clinical methods and materials

SJ Nagel, L Helland, RW Woodroffe, LA Frizon… - … : Technology at the …, 2019 - Elsevier
Introduction We are developing a novel intradural spinal cord stimulator for treatment of
neuropathic pain and spasticity. A key feature is the means by which it seals the dura mater …

Finite-element study of the performance characteristics of an intradural spinal cord stimulator

NM Grosland, GT Gillies… - Journal of …, 2014 - asmedigitalcollection.asme.org
We have used finite-element (FE) modeling to investigate the mechanical compliance,
positional stability and contact pressures associated with a novel type of spinal cord …