Proliferating cells need to produce a large amount of energy and, at the same time, need to
maintain a constant supply of biosynthetic precursors of macromolecules that are used as …

While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the
treatment of breast cancer, the orphan estrogen-related receptors (ERRs) represent novel …

The effects and mechanisms of bisphenol A (BPA) on the development of breast cancer are
still not well illustrated. The present study revealed that nanomolar BPA significantly …

Expression of estrogen-related receptor α (ERRα) has recently been shown to carry
negative prognostic significance in breast and ovarian cancers. The specific role of this …

Members of the NR3B group of the nuclear receptor superfamily, known as the estrogen-
related receptors (ERRs), were the first orphan receptors to be identified two decades ago …

Estrogen-related receptor α (ESRRA) functions as a transcription factor and regulates the
expression of several genes, such as WNT11 and OPN. Up-regulation of ESRRA has been …

High expression of the estrogen receptor-related receptor (ERR)-α in human tumors is
correlated to a poor prognosis, suggesting an involvement of the receptor in cell …

Bone metastasis is a complication occurring in up to 70% of advanced breast cancer
patients. The estrogen receptor-related receptor alpha (ERRα) has been implicated in breast …

Adaptation of cancer cells to a hypoxic microenvironment is important for their facilitated
malignant growth and advanced development. One major mechanism mediating the hypoxic …

The estrogen-related receptor alpha (ERRα) is a primary regulator of mitochondrial energy
metabolism, function and dynamics, and has been implicated in autophagy and immune …