Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Sesquiterpenoids, and specifically sesquiterpene lactones from Asteraceae, may play a
highly significant role in human health, both as part of a balanced diet and as …

Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Traditional Chinese medicine commands a unique position among all traditional medicines
because of its 5000 years of history. Our own interest in natural products from traditional …

Highlights•This article highlights phases in parthenolide (PTL) lead anticancer drug
development.•PTL structure–activity relationship studies reveal properties required for …

Recent studies have described malignant stem cells as central to the initiation, growth, and
potential relapse of acute and chronic myelogenous leukemia (AML and CML). Because of …

For 6 decades, Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical
Chemistry has been a standard in the literature of medicinal chemistry. Generations of …

The botanical collections of early explorers and the later ethnobotany have played important
roles in the development of new drugs for many centuries. In the middle of the last century …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …