In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Adoptive cell therapy using chimeric antigen receptor (CAR) technology is one of the most
advanced engineering platforms for cancer immunotherapy. CAR-T cells have shown …

Chimeric antigen receptor (CAR)-NK cell therapy has the advantages of a low incidence of
side effects and a low cost. However, the clinical outcomes are not satisfactory due to limited …

Natural killer (NK) cells are a part of innate immunity that can be activated rapidly in
response to malignant transformed cells without prior sensitization. Engineering NK cells to …

Natural killer (NK) cells are cellular components of the innate immune system that can
recognize and suppress the proliferation of cancer cells. NK cells can eliminate cancer cells …

Sorafenib, FDA-approved therapy for patients with advanced hepatocellular carcinoma
(HCC), leads to limited improvement in overall survival. However, it may indirectly impact the …

Natural killer (NK) cells are a subset of cytotoxic lymphocytes within the innate immune
system. While they are naturally cytotoxic, genetic modifications can enhance their tumor …

As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-
based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4+ T cells, CD8+ T …

Background Natural killer (NK) cells have gained considerable attention and hold great
potential for their application in tumor immunotherapy. This is mainly due to their MHC …