Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways
Cardiovascular diseases are a major cause of human death worldwide. Excessive
proliferation of vascular smooth muscle cells contributes to the etiology of such diseases …
proliferation of vascular smooth muscle cells contributes to the etiology of such diseases …
Emerging mechanisms of pulmonary vasoconstriction in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) and potential therapeutic targets
H Karmouty-Quintana, RA Thandavarayan… - International journal of …, 2020 - mdpi.com
The 1918 influenza killed approximately 50 million people in a few short years, and now, the
world is facing another pandemic. In December 2019, a novel coronavirus named severe …
world is facing another pandemic. In December 2019, a novel coronavirus named severe …
Exercise-induced signaling pathways to counteracting cardiac apoptotic processes
HA Pahlavani - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Cardiovascular diseases are the most common cause of death in the world. One of the major
causes of cardiac death is excessive apoptosis. However, multiple pathways through …
causes of cardiac death is excessive apoptosis. However, multiple pathways through …
miR-223 reverses experimental pulmonary arterial hypertension
J Meloche, M Le Guen, F Potus… - … of Physiology-Cell …, 2015 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is a devastating disease affecting lung vasculature.
The pulmonary arteries become occluded due to increased proliferation and suppressed …
The pulmonary arteries become occluded due to increased proliferation and suppressed …
DNA damage and pulmonary hypertension
B Ranchoux, J Meloche, R Paulin, O Boucherat… - International journal of …, 2016 - mdpi.com
Pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure over 25
mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of …
mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of …
Ion channels in pulmonary hypertension: a therapeutic interest?
M Lambert, V Capuano, A Olschewski… - International journal of …, 2018 - mdpi.com
Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …
SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension
R Walters, E Vasilaki, J Aman, CN Chen, Y Wu… - Circulation, 2023 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is a rare disease characterized by
remodeling of the pulmonary arteries, increased vascular resistance, and right-sided heart …
remodeling of the pulmonary arteries, increased vascular resistance, and right-sided heart …
Lung perfusion assessment in children with long‐COVID: A pilot study
DA Pizzuto, D Buonsenso, R Morello… - Pediatric …, 2023 - Wiley Online Library
Background There is increasing evidence that chronic endotheliopathy can play a role in
patients with Post‐Covid Condition (PCC, or Long Covid) by affecting peripheral …
patients with Post‐Covid Condition (PCC, or Long Covid) by affecting peripheral …
[HTML][HTML] Mechanistic and therapeutic perspectives of baicalin and baicalein on pulmonary hypertension: A comprehensive review
L Cui, T Yuan, Z Zeng, D Liu, C Liu, J Guo… - Biomedicine & …, 2022 - Elsevier
Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …
Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension
AL Frump, S Bonnet… - American Journal of …, 2018 - journals.physiology.org
Right ventricular (RV) function is the primary prognostic factor for both morbidity and
mortality in pulmonary hypertension (PH). RV hypertrophy is initially an adaptive …
mortality in pulmonary hypertension (PH). RV hypertrophy is initially an adaptive …