Cancer-associated fibroblasts (CAFs) are the prominent stromal cell population in the tumor
microenvironment (TME), which play an indispensable role in cancer progression and …

Therapy resistance remains a huge challenge for current breast cancer treatments.
Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for …

Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast
function play critical roles in bone formation, which is a highly regulated process. Long …

The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …

The prognosis of lung cancer is poor with few effective therapies. Targeting ferroptosis is a
new promising strategy for cancer therapy. LINC00641 has been involved in several …

Autophagy is an essential recycling and quality control pathway which preserves cellular
and organismal homeostasis. As a catabolic process, autophagy degrades damaged and …

Ferroptosis is a regulated cell death process initiated by iron-dependent phospholipid
peroxidation and is mainly suppressed by GPX4-dependent and FSP1-dependent …

Abstract Background Circular RNAs (circRNAs) have been shown to play diverse biological
functions in the progression of multiple diseases. However, the impacts of circRNAs on …

The p53-dependent ubiquitin ligase Pirh2 regulates a number of proteins involved in
different cancer-associated processes. Targeting the p53 family proteins, Chk2, p27Kip1 …

As the most abundant internal mRNA modification in eukaryotic cells, N 6-methyladenosine
(m6A) has emerged as an important regulator of gene expression and has a profound …