Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

The colony-stimulating factor-1 receptor (CSF-1R) kinase regulates tissue macrophage
homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in …

Microglial surveillance is a key feature of brain physiology and disease. Here, we found that
Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By …

Obesity affects> 600 million people worldwide, a staggering number that appears to be on
the rise. One of the lesser known consequences of obesity is its deleterious effects on …

Epilepsy has remained a significant social concern and financial burden globally. Current
therapeutic strategies are based primarily on neurocentric mechanisms that have not proven …

CX3CR1, one of the highest expressed genes in microglia in mice and humans, is
implicated in numerous microglial functions. However, the molecular mechanisms …

Microglia are immune cells that play a crucial role in maintaining brain homeostasis. Among
the mechanisms of communication between microglia and neurons, the CX3CL1/CX3CR1 …

Seizures are common in humans with various etiologies ranging from congenital aberrations
to acute injuries that alter the normal balance of brain excitation and inhibition. A notable …

Microglia play key roles in the post‐ischemic inflammatory response and damaged tissue
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …

Microglia, the resident immune cells of the brain, perform elaborate surveillance in which
they physically interact with neuronal elements. A novel form of microglia–neuron interaction …