Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …

The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …

Spatial proteomics technologies have revealed an underappreciated link between the
location of cells in tissue microenvironments and the underlying biology and clinical …

Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …

Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …

Native pancreatic islets interact with neighboring cells by establishing three-dimensional
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …