[PDF][PDF] β-cell Exhaustion and Islet Microenviron-ment: The Role of Local Vascular Network
PRV Local - Revista Portuguesa de Diabetes, 2024 - revportdiabetes.com
The pancreas, a crucial organ of the endocrine system, is structurally organized in the islets
of Langerhans. The islet microenvironment, comprising mesenchymal, vascular endothelial …
of Langerhans. The islet microenvironment, comprising mesenchymal, vascular endothelial …
ALK5 inhibition maintains islet endothelial cell survival but does not enhance islet graft revascularisation or function
AJF King, CE Clarkin, ALF Austin… - Hormone and …, 2015 - thieme-connect.com
Islet transplantation is a potential treatment for Type 1 diabetes but long term graft function is
suboptimal. The rich supply of intraislet endothelial cells diminishes rapidly after islet …
suboptimal. The rich supply of intraislet endothelial cells diminishes rapidly after islet …
Strategies for Vascularizing Pancreatic Islets and Stem Cell–Derived Islet Organoids
I Banerjee - Current Transplantation Reports, 2021 - Springer
Abstract Purpose of Review Efficiency of revascularization is one of the key factors dictating
the success of islet transplantation, concerning both donor islets and the future of human …
the success of islet transplantation, concerning both donor islets and the future of human …
Gene expression profiles of glucose toxicity‐exposed islet microvascular endothelial cells
M Liu, W Lu, Q Hou, B Wang, Y Sheng, Q Wu… - …, 2018 - Wiley Online Library
Objective Islet microcirculation is mainly composed by IMEC s. The aim of the study was to
investigate the differences in gene expression profiles of IMEC s upon glucose toxicity …
investigate the differences in gene expression profiles of IMEC s upon glucose toxicity …
Skin deep: from dermal fibroblasts to pancreatic beta cells
GS Manzar, EM Kim, P Rotti, N Zavazava - Immunologic research, 2014 - Springer
Abstract Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell
destruction induced by autoantibodies and autoreactive T cells. After significant reduction of …
destruction induced by autoantibodies and autoreactive T cells. After significant reduction of …
Tricultured cell sheets develop into functional pancreatic islet tissue with a vascular network
Methods to induce islet β-cells from induced pluripotent stem cells or embryonic stem cells
have been established. However, islet β-cells are susceptible to apoptosis under hypoxic …
have been established. However, islet β-cells are susceptible to apoptosis under hypoxic …
Diabètes, vascularisation pancréatique et pancréas exocrine
L Alexandre-Heymann - 2021 - theses.hal.science
La régulation glycémique, chez l'humain comme chez l'animal, dépend de la sécrétion
d'insuline. Les différents types de diabète sont ainsi liés à des dysfonctionnements …
d'insuline. Les différents types de diabète sont ainsi liés à des dysfonctionnements …
Exploring β-Cell Function and Heterogeneity in Obese SM/J Mice
M Miranda - 2021 - search.proquest.com
Pancreatic β-cells perform glucose-stimulated insulin secretion, a process required to
maintain systemic glucose homeostasis. Obesity promotes glycemic and inflammatory …
maintain systemic glucose homeostasis. Obesity promotes glycemic and inflammatory …
Challenges and strategies in tissue engineering for improved β-cell replacement therapies through an understanding of normal pancreatic anatomy and physiology
N Kattner, PO Carlsson, WE Scott III - Journal of Immunology and …, 2021 - Elsevier
Objectives Islet transplantation is a treatment option for patients with type 1 diabetes and
recurrent life-threatening hypoglycaemia. Pancreatic tissue is dissociated, and islets are …
recurrent life-threatening hypoglycaemia. Pancreatic tissue is dissociated, and islets are …