[HTML][HTML] Zika Virus: A Neurotropic Warrior against High-Grade Gliomas—Unveiling Its Potential for Oncolytic Virotherapy

MA Calderón-Peláez, SJ Maradei Anaya… - Viruses, 2024 - mdpi.com
Gliomas account for approximately 75–80% of all malignant primary tumors in the central
nervous system (CNS), with glioblastoma multiforme (GBM) considered the deadliest …

[HTML][HTML] Ultrastructural and functional characterization of mitochondrial dynamics induced by human respiratory syncytial virus infection in HEp-2 Cells

I Lara-Hernandez, JC Muñoz-Escalante, S Bernal-Silva… - Viruses, 2023 - mdpi.com
Human respiratory syncytial virus (hRSV) is the leading cause of acute lower respiratory
tract infections in children under five years of age and older adults worldwide. During hRSV …

[HTML][HTML] Zika Virus Neuropathogenesis—Research and Understanding

AD Metzler, H Tang - Pathogens, 2024 - mdpi.com
Zika virus (ZIKV), a mosquito-borne flavivirus, is prominently associated with microcephaly in
babies born to infected mothers as well as Guillain-Barré Syndrome in adults. Each cell type …

[HTML][HTML] Construction of a chikungunya virus, replicon, and helper plasmids for transfection of mammalian cells

M Colunga-Saucedo, EI Rubio-Hernandez… - Viruses, 2022 - mdpi.com
The genome of Alphaviruses can be modified to produce self-replicating RNAs and virus-
like particles, which are useful virological tools. In this work, we generated three plasmids for …

[HTML][HTML] Causes of microcephaly in human—theoretical considerations

M Heide, WB Huttner - Frontiers in neuroscience, 2023 - frontiersin.org
As is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding
the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms …

Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV

CM Gomes, MJ Sebastião, G Silva, F Moura… - … in Bioengineering and …, 2024 - frontiersin.org
Introduction: Engineered 3D models employing human induced pluripotent stem cell
(hiPSC) derivatives have the potential to recapitulate the cell diversity and structure found in …

Rational design and production of a chimeric antigen targeting Zika virus that induces neutralizing antibodies in mice

A Miranda-López, O González-Ortega… - Vaccine, 2024 - Elsevier
The Zika virus (ZIKV) is considered a public health problem worldwide due to its association
with the development of microcephaly and the Guillain-Barré syndrome. Currently, there is …

Congenital Zika virus infection impacts on male mouse offspring's reproductive biology

NT Wnuk, AFA Figueiredo, T de Oliveira Farias… - …, 2024 - rep.bioscientifica.com
In brief Congenital ZIKV infection promotes alarming effects on male offspring's reproductive
biology. This study showed the presence of the ZIKV antigen in the testis parenchyma …

Single-cell RNA sequencing of iPSC-derived brain organoids reveals Treponema pallidum infection inhibiting neurodevelopment

QY Xu, YJ Wang, Y He, XQ Zheng, ML Tong, Y Lin… - bioRxiv, 2024 - biorxiv.org
Congenital syphilis is a vertically transmitted bacterial infection caused by Treponema
pallidum, often causing multidomain neurodevelopmental disabilities. However, little is …

Caracterización ultraestructural de la infección in vitro del virus sincicial respiratorio

I Lara Hernández - REPOSITORIO NACIONAL CONACYT, 2023 - ninive.uaslp.mx
Human respiratory syncytial virus (hRSV) is the leading cause of acute lower respiratory
tract infections in children under five years of age and older adults worldwide. During hRSV …