Lysosomal cell death at a glance
S Aits, M Jäättelä - Journal of cell science, 2013 - journals.biologists.com
Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …
[HTML][HTML] Lipid metabolism, apoptosis and cancer therapy
C Huang, C Freter - International journal of molecular sciences, 2015 - mdpi.com
Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …
Caspase-7 activates ASM to repair gasdermin and perforin pores
Among the caspases that cause regulated cell death, a unique function for caspase-7 has
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …
Bucket lists must be completed during cell death
Regulated cell death occurs in many forms, including apoptosis, pyroptosis, necroptosis,
and NETosis. Most obviously, the purpose of these pathways is to kill the cell. However …
and NETosis. Most obviously, the purpose of these pathways is to kill the cell. However …
Lysosomes and lysosomal cathepsins in cell death
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …
Role of ceramides in nonalcoholic fatty liver disease
M Pagadala, T Kasumov, AJ McCullough… - Trends in endocrinology …, 2012 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is a chronic disease with a histological spectrum
ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH). The latter is …
ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH). The latter is …
[HTML][HTML] The Niemann-Pick type diseases–A synopsis of inborn errors in sphingolipid and cholesterol metabolism
FW Pfrieger - Progress in lipid research, 2023 - Elsevier
Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …
underlying mechanisms and the development of efficient therapies represent formidable …
[HTML][HTML] Nitric oxide generated by tumor-associated macrophages is responsible for cancer resistance to cisplatin and correlated with syntaxin 4 and acid …
C Perrotta, D Cervia, I Di Renzo, C Moscheni… - Frontiers in …, 2018 - frontiersin.org
Tumor microenvironment is fundamental for cancer progression and chemoresistance.
Among stromal cells tumor-associated macrophages (TAMs) represent the largest …
Among stromal cells tumor-associated macrophages (TAMs) represent the largest …
[HTML][HTML] Secretory sphingomyelinase in health and disease
J Kornhuber, C Rhein, CP Müller, C Mühle - Biological chemistry, 2015 - degruyter.com
Acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, hydrolyzes
sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single …
sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single …
The mechanism of skin lipids influencing skin status
Y Jia, Y Gan, C He, Z Chen, C Zhou - Journal of dermatological science, 2018 - Elsevier
Skin lipids, compose of sebocyte-, keratinocyte-, and microbe-derived lipids, dramatically
influence skin status by different mechanisms.(I) Physical chemistry function: They are …
influence skin status by different mechanisms.(I) Physical chemistry function: They are …