From fibre to function: are we accurately representing muscle architecture and performance?

J Charles, R Kissane, T Hoehfurtner… - Biological …, 2022 - Wiley Online Library
The size and arrangement of fibres play a determinate role in the kinetic and energetic
performance of muscles. Extrapolations between fibre architecture and performance …

Slow or fast: Implications of myofibre type and associated differences for manifestation of neuromuscular disorders

EM Lloyd, GJ Pinniger, RM Murphy… - Acta …, 2023 - Wiley Online Library
Many neuromuscular disorders can have a differential impact on a specific myofibre type,
forming the central premise of this review. The many different skeletal muscles in mammals …

Three-dimensional volumetric muscle reconstruction of the Australopithecus afarensis pelvis and limb, with estimations of limb leverage

ALA Wiseman - Royal Society Open Science, 2023 - royalsocietypublishing.org
To understand how an extinct species may have moved, we first need to reconstruct the
missing soft tissues of the skeleton, which rarely preserve, with an understanding of …

The association between muscle architecture and muscle spindle abundance

RWP Kissane, JP Charles, RW Banks, KT Bates - Scientific Reports, 2023 - nature.com
Across the human body, skeletal muscles have a broad range of biomechanical roles that
employ complex proprioceptive control strategies to successfully execute a desired …

Why does the metabolic cost of walking increase on compliant substrates?

B Grant, J Charles, B Geraghty… - Journal of the …, 2022 - royalsocietypublishing.org
Walking on compliant substrates requires more energy than walking on hard substrates but
the biomechanical factors that contribute to this increase are debated. Previous studies …

Evaluation of musculoskeletal models, scaling methods, and performance criteria for estimating muscle excitations and fiber lengths across walking speeds

I Luis, M Afschrift, F De Groote… - … in Bioengineering and …, 2022 - frontiersin.org
Muscle-driven simulations have been widely adopted to study muscle-tendon behavior;
several generic musculoskeletal models have been developed, and their biofidelity …

Uncertainty in muscle–tendon parameters can greatly influence the accuracy of knee contact force estimates of musculoskeletal models

SH Hosseini Nasab, CR Smith, A Maas… - … in Bioengineering and …, 2022 - frontiersin.org
Understanding the sources of error is critical before models of the musculoskeletal system
can be usefully translated. Using in vivo measured tibiofemoral forces, the impact of …

Skeletal muscle function underpins muscle spindle abundance

RWP Kissane, JP Charles… - Proceedings of the …, 2022 - royalsocietypublishing.org
Muscle spindle abundance is highly variable within and across species, but we currently
lack any clear picture of the mechanistic causes or consequences of this variation. Previous …

Evolutionary biomechanics: hard tissues and soft evidence?

S Broyde, M Dempsey, L Wang… - … of the Royal …, 2021 - royalsocietypublishing.org
Biomechanical modelling is a powerful tool for quantifying the evolution of functional
performance in extinct animals to understand key anatomical innovations and selective …

American Society of Biomechanics Journal of Biomechanics Award 2022: Computer models do not accurately predict human muscle passive muscle force and fiber …

LS Persad, BI Binder-Markey, AY Shin, RL Lieber… - Journal of …, 2023 - Elsevier
Musculoskeletal models are valuable for studying and understanding the human body in a
variety of clinical applications that include surgical planning, injury prevention, and …