Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

[HTML][HTML] Innate inflammation and synovial macrophages in osteoarthritis pathophysiology

TM Griffin, CR Scanzello - Clinical and experimental rheumatology, 2019 - ncbi.nlm.nih.gov
Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

[HTML][HTML] Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review

P Dainese, KV Wyngaert, S De Mits, R Wittoek… - Osteoarthritis and …, 2022 - Elsevier
Objective To systematically review the literature on the relationship between markers of
inflammation and pain in patients with knee osteoarthritis (OA). Methods We searched …

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and …

M Dai, B Sui, Y Xue, X Liu, J Sun - Biomaterials, 2018 - Elsevier
Cartilage lesions in degenerative osteoarthritis (OA) are involved with pathological
microenvironmental alterations induced by inflammatory macrophages, and apoptotic and/or …

Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy

T Gui, L Luo, B Chhay, L Zhong, Y Wei, L Yao, W Yu… - Biomaterials, 2022 - Elsevier
Oxidative stress and the reactive oxygen species (ROS) have important roles in
osteoarthritis (OA) development and progression. Scavenging ROS by exogenous …

[HTML][HTML] Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading

L Chen, JJY Zheng, G Li, J Yuan, JR Ebert, H Li… - Journal of orthopaedic …, 2020 - Elsevier
Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause
significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and …

Pathophysiological perspective of osteoarthritis

MHM Yunus, A Nordin, H Kamal - Medicina, 2020 - mdpi.com
Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …

SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect

B Zhang, H Chen, J Ouyang, Y Xie, L Chen, Q Tan… - Autophagy, 2020 - Taylor & Francis
Synovitis is implicated in the pathology of osteoarthritis (OA) and significantly contributes to
the development of OA. As a noninvasive physical therapy, low-intensity pulsed ultrasound …

A review on segmentation of knee articular cartilage: from conventional methods towards deep learning

S Ebrahimkhani, MH Jaward, FM Cicuttini… - Artificial intelligence in …, 2020 - Elsevier
In this paper, we review the state-of-the-art approaches for knee articular cartilage
segmentation from conventional techniques to deep learning (DL) based techniques. Knee …

Best evidence rehabilitation for chronic pain part 5: osteoarthritis

D Rice, P McNair, E Huysmans, J Letzen… - Journal of clinical …, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which
most commonly affects the joints of the knee, hip, and hand. To date, there are no …