The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

The interindividual genetic variations in drug metabolizing enzymes and transporters
influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease
inhibitor PF-07321332 (nirmatrelvir), in combination with ritonavir (Paxlovid), was recently …

Interest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration
holds promise for kinetic isotope effect (KIE) regulated fine‐tuning of API performance …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Aberrant activation of FGFR has been linked to the pathogenesis of many tumor types.
Selective inhibition of FGFR has emerged as a promising approach for cancer treatment …

Currently, herbal and dietary supplements have been widely applied to prevent and treat
various diseases. However, the potential toxicities and adverse reactions of herbal and …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

The interaction between son of sevenless 1 (SOS1) gene and Kirsten rat sarcoma viral
oncogene (KRAS) is crucial for activating signals of proliferation and survival in a range of …

Every week, articles disclosing new antifungal leads reported as promising starting points for
optimization projects are published. In many cases, the mechanism that accounts for their …