The differentiation of primordial germ cells (PGCs) occurs during early embryonic
development and is critical for the survival and fitness of sexually reproducing species. Here …

Fish, like many other animals, have two major cell lineages, namely the germline and soma.
The germ-soma separation is one of the earliest events of embryonic development. Germ …

Sex is pivotal for reproduction, healthcare and evolution. In the fish medaka, the Y-
chromosomal dmy (also dmrt1bY) serves the sex determiner, which activates dmrt1 for male …

Recently, evidence has been provided for multiple regulatory functions of progestins during
the late mitotic and meiotic phases of spermatogenesis in teleost fish. For example, our …

The germline definition in metazoans was first based on few bilaterian models. As a result,
gene function interpretations were often based on phenotypes observed in those models …

Spermatogonial stem cells (SSCs) are the germline stem cells that are essential for the
maintenance of spermatogenesis in the testis. However, it has not been sufficiently …

Gametogenesis is a complicated biological process by which sperm and egg are produced
for genetic transmission between generations. In many animals, the germline is segregated …

Primordial germ cell (PGC) specification occurs early in development. PGC specifiers have
been identified in Drosophila, mouse, and human but remained elusive in most animals …

Reproduction is required for the survival of all animals, yet few reproductive genes have
been shown to have a conserved requirement for fertility across the animal kingdom …

The DAZ family of genes are important fertility factors in animals, including humans. The
family consists of Y-linked DAZ, and autosomal homologs Boule and Dazl. All three genes …