Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …

Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Problems arising during translation of mRNAs lead to ribosome stalling and collisions that
trigger a series of quality control events. However, the global cellular response to ribosome …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …