Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …

Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

One goal of regenerative medicine is to instructively convert adult cells into other cell types
for tissue repair and regeneration. Although isolated examples of adult cell reprogramming …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Laminins are a large family of conserved, multidomain trimeric basement membrane
proteins that contribute to the structure of extracellular matrix and influence the behavior of …

Advances in understanding the role of vascular endothelial growth factor (VEGF) in normal
physiology are giving insight into the basis of adverse effects attributed to the use of VEGF …

Recruitment and retention of leukocytes at a site of blood vessel growth are crucial for
proper angiogenesis and subsequent tissue perfusion. Although critical for many aspects of …

The intricate patterning processes that establish the complex vascular system during
development depend on a combination of intrinsic pre-patterning and extrinsic responses to …