Landscape of NRXN1 Gene Variants in Phenotypic Manifestations of Autism Spectrum Disorder: A Systematic Review

JN Cooper, J Mittal, A Sangadi, DL Klassen… - Journal of Clinical …, 2024 - mdpi.com
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition
characterized by social communication challenges and repetitive behaviors. Recent …

[HTML][HTML] Parenting behaviors in mice: olfactory mechanisms and features in models of autism spectrum disorders

A Dudas, TS Nakahara, LP Pellissier… - … & Biobehavioral Reviews, 2024 - Elsevier
Rodents, along with numerous other mammals, heavily depend on olfactory cues to
navigate their social interactions. Processing of olfactory sensory inputs is mediated by …

[HTML][HTML] Loss of interleukin 1 signaling causes impairment of microglia-mediated synapse elimination and autistic-like behaviour in mice

A Borreca, C Mantovani, G Desiato, I Corradini… - Brain, Behavior, and …, 2024 - Elsevier
In the last years, the hypothesis that elevated levels of proinflammatory cytokines contribute
to the pathogenesis of neurodevelopmental diseases has gained popularity. IL-1 is one of …

Fluorene-9-bisphenol acts on the gut-brain axis by regulating oxytocin signaling to disturb social behaviors in zebrafish

S Zhang, P Mi, J Luan, M Sun, X Zhao, X Feng - Environmental Research, 2024 - Elsevier
Previous studies have identified the exposure to ubiquitous environmental endocrine
disruptors may be a risk factor of neurological disorders. However, the effects of fluorene-9 …

Changes in neuroinflammatory markers and microglial density in the hippocampus and prefrontal cortex of the C58/J mouse model of autism

JF Duarte‐Campos… - European Journal of …, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) is a diverse group of neurodevelopmental conditions with
complex origins. Individuals with ASD present various neurobiological abnormalities …

Detection of abnormal behaviors in prenatal Poly (I: C) exposed mice in a group‐rearing environment

M Komada, N Kiriyama, R Sugiyama… - Congenital …, 2024 - Wiley Online Library
During pregnancy, the maternal environment is critical for normal ontogeny and central
nervous system development. Occasionally, prenatal exposure to environmental factors …

Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally

R Zhao, B Ren, Y Xiao, J Tian, Y Zou, J Wei, Y Qi, A Hu… - bioRxiv, 2024 - biorxiv.org
Homeostatic plasticity maintains the stability of functional brain networks. The axon initial
segment (AIS), where action potentials start, undergoes dynamic adjustment to exert …

Distinct functions of parvalbumin and somatostatin interneurons in the anterior cingulate cortex result in heterogeneity of social interaction impairments

S Wu, C Qi, W Sima, H Miao, E Hu, J Ge, M Deng… - 2024 - researchsquare.com
The anterior cingulate cortex (ACC) serves as a core region in social networks, and
impairments in this area have been identified in autism spectrum disorders. Our prior …

Dynamic population coding of social novelty in the insular cortex

M Sato, E Overton, S Fujima, T Takumi - bioRxiv, 2024 - biorxiv.org
The familiarity of socially interacting peers has a profound impact on behavior, but little is
known about the neuronal representations distinguishing familiar from novel conspecifics …

Flee or Freeze: The Differential Role of Amygdala Subregions in Fear and Avoidance

X Li - 2024 - digital.lib.washington.edu
Fear is a powerful emotion that is crucial to the survival in a complex environment. The
amygdala, a key brain region implicated in processing fear, is not homogenous but …