Background Colorectal cancer (CRC) is a major contributor to morbidity and mortality related
to cancer. Only~ 5% of all CRCs occur as a result of pathogenic variants in well‐defined …

Colorectal cancer (CRC) is a common malignant tumor of the digestive system worldwide,
associated with hereditary genetic features. CRC with a Mendelian genetic predisposition …

Mutational processes in germline and in somatic cells are vastly different, and it remains
unclear how the same genetic background affects somatic and transmissible mutations …

Precision medicine, a concept that has recently emerged and has been widely discussed,
emphasizes tailoring medical care to individuals largely based on information acquired from …

Breast cancer (BRCA) remains the leading cause of cancer morbidity and mortality
worldwide. In the present study, we identified novel biomarkers expressed during estradiol …

Background Lynch syndrome (LS) is an inherited disorder associated with genetic
predisposition to endometrial, colorectal, ovarian, and other cancers. There is consensus for …

Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute
GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown …

ABSTRACT DNA polymerase kappa is a Y‐family polymerase that participates to bypass the
damaged DNA known as translesion synthesis (TLS) polymerase. Higher frequency of …

Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC)
staining remain without any identifiable germline mutation of DNA mismatch repair (MMR) …

Molecular pathology is playing an increasingly important role in the treatment and overall
management of patients with colorectal carcinoma. Three distinct genetic pathways have …