[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

[HTML][HTML] Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

RE Mukamel, RE Handsaker, MA Sherman, AR Barton… - Science, 2021 - science.org
Many human proteins contain domains that vary in size or copy number because of variable
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …

[HTML][HTML] Human genetics and the causal role of lipoprotein (a) for various diseases

F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a highly atherogenic lipoprotein that is under strong
genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy …

[HTML][HTML] A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]

S Mack, S Coassin, R Rueedi, NA Yousri… - Journal of lipid …, 2017 - ASBMB
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

[HTML][HTML] Diet and Lp (a): does dietary change modify residual cardiovascular risk conferred by Lp (a)?

B Enkhmaa, KS Petersen, PM Kris-Etherton… - Nutrients, 2020 - mdpi.com
Lipoprotein (a)[Lp (a)] is an independent, causal, genetically determined risk factor for
cardiovascular disease (CVD). We provide an overview of current knowledge on Lp (a) and …

A polymorphism in the protease-like domain of apolipoprotein (a) is associated with severe coronary artery disease

MM Luke, JP Kane, DM Liu, CM Rowland… - … , and vascular biology, 2007 - Am Heart Assoc
Objectives—The purpose of this study was to identify genetic variants associated with
severe coronary artery disease (CAD). Methods and Results—We used 3 case-control …

Lipoprotein (a): A missing culprit in the management of athero‐thrombosis?

G Ferretti, T Bacchetti, TP Johnston… - Journal of Cellular …, 2018 - Wiley Online Library
Lipoprotein (a) Lp (a) is a cholesterol‐rich, LDL‐like particle that is independently
associated with an increased risk for ischemic heart disease, atherosclerosis, thrombosis …

The renaissance of lipoprotein (a): brave new world for preventive cardiology?

KL Ellis, MB Boffa, A Sahebkar, ML Koschinsky… - Progress in Lipid …, 2017 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a highly heritable cardiovascular risk factor. Although
discovered more than 50 years ago, Lp (a) has recently re-emerged as a major focus in the …

[HTML][HTML] Lipoprotein (a): a historical appraisal

KM Kostner, GM Kostner - Journal of Lipid Research, 2017 - ASBMB
Initially, lipoprotein (a)[Lp (a)] was believed to be a genetic variant of lipoprotein (Lp)-B.
Because its lipid moiety is almost identical to LDL, Lp (a) has been deliberately considered …