Individuals who smoke generally do so with the knowledge of potential consequences to
their own health. What is rarely considered are the effects of smoking on their future children …

A problem of 'missing heritability'has been identified following recent genome-wide
association (GWA) studies of single nucleotide polymorphisms (SNPs) associated with …

Extrachromosomal circular DNA (eccDNA) is ubiquitous in eukaryotic organisms, and has
been noted for more than 3 decades. eccDNA occurs in normal tissues and in cultured cells …

Despite the presence of known mutagens and carcinogens in cigarette smoke, there is
currently no evidence to show that smoking, or exposure to cigarette smoke, can result in …

Our understanding of genomic reorganization, the mechanics of genomic transmission to
offspring during germ line formation, and how these structural changes contribute to the …

Myelodysplastic syndromes (MDSs) pose an important diagnostic and treatment challenge
because of the genetic heterogeneity and poorly understood biology of the disease. To …

Exposure to particulate matter (PM) has been associated with lung cancer risk in
epidemiology investigations. Elemental components of PM have been suggested to have …

Background Ancestral reconstructions of mammalian genomes have revealed that
evolutionary breakpoint regions are clustered in regions that are more prone to break and …

In biological sequences, tandem repeats consist of tens to hundreds of residues of a
repeated pattern, such as atgatgatgatgatg ('atg'repeated), often the result of replication …

Genetic variation has long been thought associated with common complex disease and has
therefore been widely studied. Genetic variation in the human genome is present in many …