Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but
important functions. Since the first atomic structure of a prokaryotic potassium channel …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically
excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully …

Slo1 is a Ca2+-and voltage-activated K+ channel that underlies skeletal and smooth muscle
contraction, audition, hormone secretion and neurotransmitter release. In mammals, Slo1 is …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Hair cells are mechanosensors for the perception of sound, acceleration, and fluid motion.
Mechanotransduction channels in hair cells are gated by tip links, which connect the …