Akt signaling in macrophage polarization, survival, and atherosclerosis

MRF Linton, JJ Moslehi, VR Babaev - International journal of molecular …, 2019 - mdpi.com
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of
macrophages, which may impact the development of atherosclerosis. Changes in Akt …

The role of vimentin intermediate filaments in the progression of lung cancer

ME Kidd, DK Shumaker, KM Ridge - American journal of respiratory …, 2014 - atsjournals.org
There is an accumulation of evidence in the literature demonstrating the integral role of
vimentin intermediate filaments (IFs) in the progression of lung cancers. Vimentin IF proteins …

Macrophage apoptosis and efferocytosis in the pathogenesis of atherosclerosis

MRF Linton, VR Babaev, J Huang, EF Linton… - Circulation …, 2016 - jstage.jst.go.jp
Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process
called efferocytosis, are crucial determinants of atherosclerosis lesion progression and …

A novel angiotensin-converting enzyme (ACE) inhibitory peptide from tilapia skin: Preparation, identification and its potential antihypertensive mechanism

Y Dong, W Yan, YQ Zhang, ZY Dai - Food Chemistry, 2024 - Elsevier
To obtain food-derived peptides with high ACE inhibitory activity, tilapia skin was pretreated
with steam explosion prior to enzymatic hydrolysis. The results showed that steam explosion …

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

E Agarwal, MG Brattain, S Chowdhury - Cellular signalling, 2013 - Elsevier
Dissemination of cancer cells to distant organ sites is the leading cause of death due to
treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the …

PROGgene: gene expression based survival analysis web application for multiple cancers

CP Goswami, H Nakshatri - Journal of clinical bioinformatics, 2013 - Springer
Background Identification of prognostic mRNA biomarkers has been done for various cancer
types. The data that are published from such studies are archived in public repositories …

Anti‐colorectal cancer targets of resveratrol and biological molecular mechanism: analyses of network pharmacology, human and experimental data

R Li, X Ma, Y Song, Y Zhang, W Xiong… - Journal of Cellular …, 2019 - Wiley Online Library
In this study, colorectal cancer (CRC)‐diseased targets and resveratrol (Res)‐associated
targets were combined and constructed by the use of grouped databases for identification of …

Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

G Cassinelli, V Zuco, L Gatti, C Lanzi… - Current medicinal …, 2013 - ingentaconnect.com
The deregulation of oncogenic signaling pathways which provide survival advantages to
tumor cells is mediated by multiple cellular networks. Among them, the PI3K-Akt-mTOR axis …

The Akt signaling pathway: an emerging therapeutic target in malignant melanoma

SRV Madhunapantula, PJ Mosca… - Cancer biology & …, 2011 - Taylor & Francis
Studies using cultured melanoma cells and patient tumor biopsies have demonstrated
deregulated PI3 kinase-Akt3 pathway activity in~ 70% of melanomas. Furthermore, targeting …

Abnormalities of signal transduction networks in chronic schizophrenia

JL McGuire, EA Depasquale, AJ Funk… - NPJ …, 2017 - nature.com
Schizophrenia is a serious neuropsychiatric disorder characterized by disruptions of brain
cell metabolism, microstructure, and neurotransmission. All of these processes require …