The influx and efflux of cells and antigens to and from the draining lymph nodes largely take
place through the subcapsular, cortical and medullary sinus systems. Recent analyses in …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

One of the characteristics of the central nervous system is the lack of a classical lymphatic
drainage system. Although it is now accepted that the central nervous system undergoes …

The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …

Lymphoedema is an oedematous condition with a specific and complex tissue biology. In
the clinical context of cancer, the pathogenesis of lymphoedema ensues most typically from …

Rationale: The formation of the blood vasculature is achieved via 2 fundamentally different
mechanisms, de novo formation of vessels from endothelial progenitors (vasculogenesis) …

Obesity is a key risk factor for metabolic and cardiovascular diseases, and although we
understand the mechanisms regulating weight and energy balance, the causes of some …

Lymphatic vasculature drains interstitial fluids, which contain the tissue's waste products,
and ensures immune surveillance of the tissues, allowing immune cell recirculation. Until …

The many interactions between the nervous and the immune systems, which are active in
both physiological and pathological states, have recently become more clearly delineated …

BACKGROUND. Lymphedema is a common condition affecting millions around the world
that still lacks approved medical therapy. Because ketoprofen, an NSAID, has been …