The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …

Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …

The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …

Aging is a physiological and progressive phenomenon in all organisms' life cycle,
characterized by the accumulation of degenerative processes triggered by several …

Although over 170 chemical modifications have been identified, their prevalence,
mechanism and function remain largely unknown. To enable integrated analysis of diverse …

Trained immunity describes the capacity of innate immune cells to develop heterologous
memory in response to certain exogenous exposures. This phenomenon mediates, at least …

Thanks to the tremendous advancement of deep sequencing and large-scale profiling,
epitranscriptomics has become a rapidly growing field. As one of the most important parts of …

Advances in sequencing technologies have empowered epitranscriptomic profiling at the
single-base resolution. Putative RNA modification sites identified from a single high …

Long noncoding RNAs (lncRNAs) are usually 5′ capped and 3′ polyadenylated, similar to
most typical mRNAs. However, recent studies revealed a type of snoRNA-related lncRNA …

Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …