Liquid chromatography coupled to atmospheric pressure ionization tandem mass
spectrometry is currently the method of choice for the quantitative determination of drugs in …

LC–MS is becoming a standard for many applications, thanks to high sensitivity and
selectivity; nevertheless, some issues are still present, particularly due to matrix effect (ME) …

Antibiotic (ATB) treatment of critically ill patients with pathophysiological injuries remains a
challenge due to the constant increase in antimicrobial resistance. Therapeutic drug …

A method was developed for the confirmatory and quantitative analysis of 30 β-lactam
antibiotic residues in bovine muscle. The method includes 12 penicillins (amoxicillin …

Phencyclidine (PCP) is a frequently abused dissociative agent. It causes confusion,
increased tendencies toward violence, and concentration-dependent cytotoxicity after entry …

Ertapenem (Invanz®) is a newly developed carbapenem β-lactam antimicrobial agent. The
drug usage in pediatric age needs an accurate drug monitoring for effective patient …

Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g
intravenous and subcutaneous (sc) infusions. Bioavailability was 99%±18% after sc …

The carbapenems are a class of a β-lactam antibiotics with a broad spectrum of antibacterial
activity. In all carbapenems, a β-lactam ring is required for their antibacterial activity. In …

This review attempts to pinpoint the importance of betalactam antibiotics, which encompass
penicillins, cephalosporins, cephamycins, carbapenems and monobactams from its …

Abstract Meropenem, linezolid, fluconazole, voriconazole, posaconazole, and vancomycin
are six important antimicrobials used for severe infections in critically ill patients listed in …