In this Minireview, we highlight recent advances in the design of transition metal complexes
for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the …

Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions
with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However …

Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS)
and to participate in different modes of cell death, such as ferroptosis, apoptosis and …

Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many
ways, from altering the activity of antioxidant enzymes to the level of transcription factors …

Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within
tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of …

As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

The tumor microenvironment plays a critical regulatory role in cancer progression, especially
in central nervous system metastases. Cancer cells within the cerebrospinal fluid (CSF) …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Iron as an important element plays crucial roles in various physiological and pathological
processes. Iron metabolism behaves in systemic and cellular two levels that usually are in …