Ovarian cancer is a lethal malignancy that has not seen a major therapeutic advance in over
30 years. We demonstrate that ovarian cancer exhibits a targetable alteration in iron …

Current oxidative stress amplifying strategies for immunogenic cell death (ICD) promotion
are mainly restricted to immune tolerance induced by adaptive cellular antioxidation, limited …

The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …

Cancer stem cells (CSCs) contribute to the initiation, recurrence, and metastasis of cancer;
however, there are still no drugs targeting CSCs in clinical application. There are several …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Acute myeloid leukaemia is a fatal disease for most patients. We have found that ferumoxytol
(Feraheme), an FDA-approved iron oxide nanoparticle for iron deficiency treatment …

Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular
mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 …

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …