[HTML][HTML] Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

V Bourganis, O Kammona, A Alexopoulos… - European Journal of …, 2018 - Elsevier
Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …

[HTML][HTML] Intranasal nanoemulsions for direct nose-to-brain delivery of actives for CNS disorders

S Bahadur, DM Pardhi, J Rautio, JM Rosenholm… - Pharmaceutics, 2020 - mdpi.com
The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

Study on the coal dust deposition fraction and site in the upper respiratory tract under different particle sizes and labor intensities

Y Cheng, H Yu, S Xie, J Zhao, Y Ye - Science of The Total Environment, 2023 - Elsevier
In order to study the dust exposure amount and coal dust deposition rule of coal miners
under different labor intensity in coal mine environment, an airflow-particle two-phase …

Airflow and particle transport in the human respiratory system

C Kleinstreuer, Z Zhang - Annual review of fluid mechanics, 2010 - annualreviews.org
Airflows in the nasal cavities and oral airways are rather complex, possibly featuring a
transition to turbulent jet-like flow, recirculating flow, Dean's flow, vortical flows, large …

[图书][B] Multiphase flow handbook

E Michaelides, CT Crowe, JD Schwarzkopf - 2016 - books.google.com
The Multiphase Flow Handbook, Second Edition is a thoroughly updated and reorganized
revision of the late Clayton Crowe's work, and provides a detailed look at the basic concepts …

[HTML][HTML] A review of respiratory anatomical development, air flow characterization and particle deposition

MS Islam, G Paul, HX Ong, PM Young, YT Gu… - International journal of …, 2020 - mdpi.com
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

In silico models of aerosol delivery to the respiratory tract—development and applications

PW Longest, LT Holbrook - Advanced drug delivery reviews, 2012 - Elsevier
This review discusses the application of computational models to simulate the transport and
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …

Study on the transport and deposition of micron-sized particles with different densities in the coal mine environment in miners

Y Cheng, H Yu, Y Ye, Y Xie, J Zhao, S Xie - Fuel, 2024 - Elsevier
To address the health problems caused by the long-term intrusion of high-concentration dust
generated in coal mining operations into the human respiratory tract, this study …

Innovative preclinical models for pulmonary drug delivery research

S Ehrmann, O Schmid, C Darquenne… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach

J Xi, PW Longest - International Journal of Heat and Mass Transfer, 2008 - Elsevier
Evaluating the health effects of inhaled submicrometer aerosols, such as combustion
particulate matter and bioaerosols, requires a thorough understanding of transport and …