Abstract Unapposed connexin 43 hemichannels (Cx43Hc) are present on sarcolemma of
cardiomyocytes. Whereas Cx43Hc remain closed during physiological conditions, their …

During early wound healing (WH) events Connexin 43 (Cx43) is down‐regulated at wound
margins. In chronic wound margins, including diabetic wounds, Cx43 expression is …

Coordinated electrical activity in the heart is supported by gap junction channels located at
the intercalated discs of cardiomyocytes. Impaired gap junctional communication between …

Rather being an inert barrier between vessel lumen and surrounding tissues, vascular
endothelium plays a key role in the maintenance of cardiovascular homeostasis. The de …

Neuronal signaling together with synapse activity in the central nervous system requires a
precisely regulated microenvironment. Recently, the blood‐brain barrier is considered as a …

Mammalian type II taste cells release the afferent neurotransmitter adenosine triphosphate
(ATP) through ATP-permeable ion channels, most likely to be connexin (Cx) and/or …

Connexins and pannexins are vertebrate transmembrane proteins that form hexameric
conduits termed hemichannels. Functional hemichannels allow the diffusional transport of …

Gap junction channels and hemichannels formed by the connexin family of proteins play
important roles in many aspects of tissue homeostasis in the brain and in other organs. In …

Gap junctions are cytoplasmic channels connecting adjacent cells and mediating their
electrical and metabolic coupling. Different cell types in the CNS express various gap …

Numerous cell types express functional connexin (Cx) hemichannels (HCs), and membrane
depolarization and/or exposure to a divalent cation-free bathing solution (DCFS) have been …