The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Neutrophils respond to myocardial ischemia–reperfusion in a manner similar to the bacterial
invasion of a host. The inflammatory-like response that follows the onset of reperfusion …

The roles of enzymatic antioxidant defenses in the natural tolerance of environmental
stresses that impose changes in oxygen availability and oxygen consumption on animals is …

Concentrations of up to 1.5 milliunits/ml xanthine oxidase (XO)(1.1 μg/ml) are found
circulating in plasma during diverse inflammatory events. The saturable, high affinity binding …

Myocardial ischemia is a major cause of morbidity and mortality in the world. Although
restoration of blood flow after prolonged ischemia is essential for cardiomyocytes salvation …

The effects of anoxic submergence (20 h at 5° C) and subsequent 24 h aerobic recovery on
the antioxidant systems of six organs were examined in freshwater turtles, Trachemys scripta …

evidence shows that they play necessary roles in normal signal transduction. 1 In low
concentrations, they are implicated as second messengers primarily through inhibition of …

Freeze-tolerant wood frogs (Rana sylvatica) must endure prolonged ischemia on freezing.
Reperfusion on thawing brings with it the potential or oxidative damage due to reactive …

Publisher Summary Oxygen is essential for most life forms. The full reduction of oxygen to H
2 O by cytochrome oxidase is a key step in the mechanism of aerobic ATP formation …