Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa.
Sleep-inducing inflammatory molecules are activated by increased waking activity and …

The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Ongoing research has highlighted the significance of the cross-play of macrophages and
mesenchymal stem cells (MSCs). Lysine-specific demethylase 6B (KDM6B) has been …

Rheumatoid arthritis (RA) represents one of the best examples of circadian fluctuations in
disease severity. Patients with RA experience stiffness, pain, and swelling in afflicted joints …

Autoimmune diseases (AIDs) refer to connective tissue inflammation caused by aberrant
autoantibodies resulting from dysfunctional immune surveillance. Most of the current …

The circadian clock adapts to the light–dark cycle and autonomously generates
physiological and metabolic rhythmicity. Its activity depends on the central suprachiasmatic …

Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor
central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is …

Background: Atherosclerosis is a medical urgency manifesting at the onset of
hypercholesterolemia and is associated with aging. Activation of PPARγ (peroxisome …

It has emerged that an interconnected relationship exists between metabolism, circadian
rhythms, and the immune system. The relationship between metabolism and circadian …

Fibroblasts are stromal cells abundant throughout tissues, including the lungs. Fibroblasts
are integral coordinators of immune cell recruitment through chemokine secretion. Circadian …