[HTML][HTML] Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience

AP Bolshakov, MY Stepanichev, YV Dobryakova… - Toxins, 2020 - mdpi.com
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates
ribosomes. Saporin itself is non-selective toxin but acquires high specificity after conjugation …

Comparative analysis of MPTP neurotoxicity in mice with a constitutive knockout of the α-synuclein gene

KD Chaprov, EV Teterina, AY Roman, TA Ivanova… - Molecular Biology, 2021 - Springer
Aggregated forms of α-synuclein are core components of pathohistological inclusions known
as Lewy bodies in substantia nigra (SN) neurons of patients with Parkinson's disease (PD) …

Estimation of metabolism of catecholamines in peripheral organs as an indicator of their desympathization under the influence of neurotoxins

VV Safandeev, AA Kolacheva, MV Ugrumov - Doklady Biochemistry and …, 2019 - Springer
Under conditions of the experimental model of Parkinson's disease at the preclinical (early)
and clinical stage—injection of mice with the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6 …

Использование нейротоксинов в фундаментальных, медицинских и биологических науках на примере 1-метил-4-фенил-1, 2, 3, 6-тетрагидропиридина (МФТП …

ВВ Сафандеев, ТА Синицкая - Токсикологический вестник, 2022 - elibrary.ru
Введение. Нейротоксины представляют собой класс химических веществ,
повреждающих нейроны. Схожим действием обладают некоторые пестициды …

A New Approach to Assessing the Extent of Degradation of the Nigrostriatal Dopaminergic System in an Experimental Model of Parkinson's Disease

VV Safandeev, MV Ugrumov - Neuroscience and Behavioral Physiology, 2020 - Springer
A characteristic feature of Parkinson's disease (PD) is the fact that it is diagnosed only at the
late,“clinical” stage due to onset of motor symptoms on the background of almost complete …