Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury.
However, the detailed mechanisms involved remain elusive. Here, we found that cyclic GMP …

Acute respiratory distress syndrome (ARDS) is a common critical illness in respiratory care
units with a huge public health burden. Despite tremendous advances in the prevention and …

Lower respiratory tract infections caused by bacteria are a major cause of death in humans
irrespective of sex, race, or geography. Indeed, accumulated data indicate greater mortality …

COPD poses a significant global public health challenge, primarily characterised by
irreversible airflow restriction and persistent respiratory symptoms. The hallmark pathology …

Streptococcus pneumoniae, a Gram-positive bacterial pathogen, causes pneumonia,
meningitis, and septicemia. Innate immune responses are critical for the control and …

Cadmium (Cd), a toxic heavy metal and carcinogen that is abundantly present in cigarette
smoke, is a cause of smoking-induced lung disease. SLC39A8 (ZIP8), a zinc transporter, is a …

The COVID-19 pandemic has inflicted millions of deaths worldwide. Despite the availability
of several vaccines and some special drugs approved for emergency use to prevent or treat …

Despite advances in antimicrobial chemotherapy and access to sophisticated intensive care
facilities, bacterial community-acquired pneumonia (CAP) continues to carry an …

The innate immune system employs C-type lectin receptors (CLRs) to recognize
carbohydrate structures on pathogens and self-antigens. The Macrophage-inducible C-type …

Context: Mogroside V, a compound isolated from Momordica grosvenori Swingle, which
belongs to the Cucurbitaceae, is a traditional Chinese medicine reported to have anti …