A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …

Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for
tumour growth, have been identified in human haematological malignancies, and solid …

Cancer contributes to 50% of deaths worldwide and new anti-tumour therapeutics with novel
mechanisms of actions are essential to develop. Metabolic inhibitors represent an important …

Cancer stem cells (CSC) have been identified in hematological malignancies and several
solid cancers. Similar to physiological stem cells, CSC are capable of self‐renewal and …

Abstract ATP Binding Cassette (ABC) transporters, widely studied in cancer for their role in
drug resistance, have been more recently also considered for their contribution to cancer …

Self‐renewing cancer stem cells (CSC) capable of spawning more differentiated tumor cell
progeny are required for tumorigenesis and neoplastic progression of leukemias and …

Thiamine (vitamin B1) is a precursor of the well-known coenzyme of central metabolic
pathways thiamine diphosphate (ThDP). Highly intense glucose oxidation in the brain …

Bringing a knowledge of enzymology into research in vivo and in situ is of great importance
in understanding systems biology and metabolic regulation. The central metabolic …

Prokaryotes, yeasts and plants synthesize thiamin (vitamin B1) via complex pathways.
Animal cells capture the vitamin through specific high‐affinity transporters essential for …