The molecular mechanisms of general anaesthetics have remained largely obscure since
their introduction into clinical practice just over 150 years ago. This review describes the …

What makes a general anesthetic a general anesthetic? We shall review first what general
anesthesia is all about and which drugs are being used as anesthetics. There is neither a …

A series of 27 analogs of the general anesthetic propofol (2, 6-diisopropylphenol) were
examined for general anesthetic activity in Xenopus laevis tadpoles and for the ability to …

Menthol and related compounds were investigated for modulation of recombinant human γ-
aminobutyric acid type A (GABAA, α1β2γ2s) receptor currents expressed in Xenopus …

Abstract What We Already Know about This Topic Recent efforts to identify new sedative-
hypnotics are based on activity in established molecular targets of anesthetics, mostly γ …

This study investigated whether the nitric oxide pathway was involved in the central effects of
Δ9‐tetrahydrocannabinol (Δ9‐THC), the major psychoactive constituent of cannabis sativa …

Propofol is a short-acting intravenous anesthetic agent suitable for induction and
maintenance of general anesthesia as well as for procedural and intensive care unit …

There has been an explosive increase in the amount of interesting information about the
physiologic and pathophysiologic roles of nitric oxide in cardiovascular, nervous, and …

The present study was performed to investigate the effect of propofol on anxiety using the
elevated plus-maze test. Groups of mice received propofol (20, 40, 60 mg/kg) or diazepam …

Background: Drug-induced conditioned place preference (CPP) is linked to the addictive
properties of the drug used. The number of studies that have investigated the effects of …