Tears have a vital function to protect and lubricate the ocular surface. Tear production,
distribution and clearance is tightly regulated by the lacrimal functional unit (LFU) to meet …

One of the most compelling features of dry eye disease (DED) is that it occurs more
frequently in women than men. In fact, the female sex is a significant risk factor for the …

Dry eye is a common, multifactorial disease currently diagnosed by a combination of
symptoms and signs. Its epidemiology and clinical presentation have many similarities with …

The word “elective” refers to medications and procedures undertaken by choice or with a
lower grade of prioritization. Patients usually use elective medications or undergo elective …

Dry eye disease (DED) is a multifactorial disorder of the ocular surface and tear homeostasis
that can result in discomfort, pain, and visual disturbance. Untreated, DED can become …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …

Background Dry eye disease (DED) is a multifactorial disease associated with ocular
surface inflammation, pain, and nerve abnormalities. We studied the peripheral and central …

Background Primary Sjogren's Syndrome (pSS) is a classic, immune-mediated, condition of
unknown aetiology characterized by focal lymphocytic infiltration of exocrine glands [1] …

Measurement of tear film breakup time (TBUT) has become a standard diagnostic procedure
in the dry eye clinic. Short TBUT-type dry eye is characterized by TBUT of less than 5 …