Significance: While atherosclerosis is an almost inevitable consequence of aging, food
preferences, lack of exercise, and other aspects of the lifestyle in many countries, the …

Introduction: Hypogonadism is the most frequently reported endocrine complication,
affecting 40%–80% of thalassemia major (TM) patients. The prevalence and severity of …

Increasing evidence suggests that free haem and iron exert vasculo‐toxic and pro‐
inflammatory effects by activating endothelial and immune cells. In the present retrospective …

Background: The aim of this study is to develop new perspectives to prevent or reduce
potential organ damage due to iron-mediated oxidation in thalassemia major patients …

Background & aims Blood transfusion therapy is lifesaving for individuals with β-thalassemia
major (β-TM). Iron burden following blood transfusion is the main cause of oxidative stress …

β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an
absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma chain and …

Background and aim β-Thalassemia major, the commonest inherited anemia worldwide is
associated with abnormalities in glucose homeostasis and serum lipids and chronic …

Abstract Objective/Background Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
and thalassemia are genetically independent hemolytic disorders. Co-inheritance of both …

Background: Atherosclerosis represents one of the major causes of morbidity in children
with β-thalassemia major (β-TM). Aim: This study was designed to investigate SIRT1-FOXO1 …

Oxidative stress is a major mechanism contributing to the progression of β-thalassemia. To
assess the effect of vitamin E and N-acetyl cysteine (NAC) as antioxidant agents on total …