The harmful use of alcohol has been estimated to cause approximately 3.3 million deaths
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …

Although drug craving has received considerable research attention over the past several
decades, to date there has been no systematic review of the general clinical significance of …

Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …

Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in
Europe. However, there has been limited research investment into ALD despite its …

Medicine is an ever-changing science. As new research and clinical experience broaden
our knowledge, changes in treatment and drug therapy are required. The authors and the …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Recent data indicate that alcohol dependence induces long-term neuroadaptations that
recruit a negative emotional state. This leads to excessive alcohol ingestion motivated by …

Alcohol use disorders (AUDs) constitute the most common form of substance abuse. The
development of AUDs involves repeated alcohol use leading to tolerance, alcohol …

Alcoholism is a chronic relapsing disorder. Major characteristics observed in alcoholics
during an initial period of alcohol abstinence are altered physiological functions and a …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …