The senescence-associated secretory phenotype and its physiological and pathological implications

B Wang, J Han, JH Elisseeff, M Demaria - Nature Reviews Molecular …, 2024 - nature.com
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

[HTML][HTML] The PTGS2/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus

E Martín-Vázquez, N Cobo-Vuilleumier… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Prostaglandins are lipid mediators involved in physiological processes, such as constriction
or dilation of blood vessels, but also pathophysiological processes, which include …

Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution

PB Ampomah, B Cai, SR Sukka, BD Gerlach… - Nature …, 2022 - nature.com
Efferocytosis, the clearance of apoptotic cells (ACs) by macrophages, is critical for tissue
resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated …

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

L Du, J Wu, Y Han, C Wu - Science Advances, 2024 - science.org
Limited motor activity due to the loss of natural structure impedes recovery in patients
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …

[HTML][HTML] The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells

A Kulesza, L Paczek, A Burdzinska - Biomedicines, 2023 - mdpi.com
The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

[HTML][HTML] Natural medicines of targeted rheumatoid arthritis and its action mechanism

X Liu, Z Wang, H Qian, W Tao, Y Zhang, C Hu… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical
manifestations of joint inflammation, bone damage and cartilage destruction, joint …

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

P Mehrotra, S Maschalidi, L Boeckaerts, C Maueröder… - Nature, 2024 - nature.com
Pyroptosis is a lytic cell death mode that helps limit the spread of infections and is also
linked to pathology in sterile inflammatory diseases and autoimmune diseases,,–. During …

[HTML][HTML] Marine-derived products as functional feed additives in aquaculture: A review

H Van Doan, P Prakash, SH Hoseinifar, E Ringø… - Aquaculture …, 2023 - Elsevier
The aquaculture industry is expanding to meet the daily requirements of humanity from high-
quality seafood. In this regard, intensive aquaculture systems are suggested, resulting in …

Role of prostaglandin E2 in macrophage polarization: Insights into atherosclerosis

W Wang, M Liang, L Wang, W Bei, X Rong, J Xu… - Biochemical …, 2023 - Elsevier
Atherosclerosis, a trigger of cardiovascular disease, poses grave threats to human health.
Although atherosclerosis depends on lipid accumulation and vascular wall inflammation …

[HTML][HTML] Fatty acid desaturation and lipoxygenase pathways support trained immunity

AV Ferreira, JC Alarcon-Barrera… - Nature …, 2023 - nature.com
Infections and vaccines can induce enhanced long-term responses in innate immune cells,
establishing an innate immunological memory termed trained immunity. Here, we show that …