The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
[HTML][HTML] The PTGS2/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus
E Martín-Vázquez, N Cobo-Vuilleumier… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Prostaglandins are lipid mediators involved in physiological processes, such as constriction
or dilation of blood vessels, but also pathophysiological processes, which include …
or dilation of blood vessels, but also pathophysiological processes, which include …
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution
Efferocytosis, the clearance of apoptotic cells (ACs) by macrophages, is critical for tissue
resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated …
resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated …
Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration
Limited motor activity due to the loss of natural structure impedes recovery in patients
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …
[HTML][HTML] The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells
A Kulesza, L Paczek, A Burdzinska - Biomedicines, 2023 - mdpi.com
The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …
understanding the molecular mechanisms responsible for these properties is still far from …
[HTML][HTML] Natural medicines of targeted rheumatoid arthritis and its action mechanism
X Liu, Z Wang, H Qian, W Tao, Y Zhang, C Hu… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical
manifestations of joint inflammation, bone damage and cartilage destruction, joint …
manifestations of joint inflammation, bone damage and cartilage destruction, joint …
Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair
Pyroptosis is a lytic cell death mode that helps limit the spread of infections and is also
linked to pathology in sterile inflammatory diseases and autoimmune diseases,,–. During …
linked to pathology in sterile inflammatory diseases and autoimmune diseases,,–. During …
[HTML][HTML] Marine-derived products as functional feed additives in aquaculture: A review
The aquaculture industry is expanding to meet the daily requirements of humanity from high-
quality seafood. In this regard, intensive aquaculture systems are suggested, resulting in …
quality seafood. In this regard, intensive aquaculture systems are suggested, resulting in …
Role of prostaglandin E2 in macrophage polarization: Insights into atherosclerosis
W Wang, M Liang, L Wang, W Bei, X Rong, J Xu… - Biochemical …, 2023 - Elsevier
Atherosclerosis, a trigger of cardiovascular disease, poses grave threats to human health.
Although atherosclerosis depends on lipid accumulation and vascular wall inflammation …
Although atherosclerosis depends on lipid accumulation and vascular wall inflammation …
[HTML][HTML] Fatty acid desaturation and lipoxygenase pathways support trained immunity
AV Ferreira, JC Alarcon-Barrera… - Nature …, 2023 - nature.com
Infections and vaccines can induce enhanced long-term responses in innate immune cells,
establishing an innate immunological memory termed trained immunity. Here, we show that …
establishing an innate immunological memory termed trained immunity. Here, we show that …